What are peptides?
Peptides are molecules made up of two or more amino acids linked together by the same peptide bonds found in proteins. Peptides are closely related to protein. In fact, when the number of amino acids is less than about 50, these molecules are called peptides while longer chains are called proteins. Peptides and proteins are present in every living cell and are responsible for many biochemical activities including acting in enzymes, hormones, antibiotics, etc.
How do peptides stimulate collagen synthesis?
Peptides perform important functions in the skin. As people age, they lose collagen which results in sagging and wrinkled skin. Since collagen is a protein composed of long chains of amino acids linked together by peptide bonds, peptides play an important role in replacing lost collagen. As collagen breaks down, the protein chains break up into smaller chains of peptides. The resulting peptide chains send signals to the body to produce more collagen.
Since peptides are small, they can penetrate the skin’s protective barriers. Applying peptides directly to the skin through well formulated delivery vehicles tricks the skin into thinking that it has lost collagen recently and needs to produce more.
What is an appropriate delivery vehicle for targeted absorption of peptides?
We know that peptides are small. This means that they will NOT penetrate the skin if they formulated and used in a thick cream, they will just end up sitting in the cream on top of the skin.
Lipid based delivery systems, such as liposomes, are most suitable for the delivery of peptides. Read more here
The cosmetic scientist who tested and formulated our peptides, has successfully created a liposome lamellar microemulsion to enhance the peptides' absorption and transport to their target cell groups.
Simply adding water to the emulsion will create a thin, elegant serum which will easily absorb into the skin. In addition it is possible to add other water and oil soluble anti aging skin actives to the microemuslion, to create a powerful and complex anti aging skin care product.
Who manufactured the peptides and the peptide lipsome microemulsion
We have spent an enormous amount of time in preparing for the sale of our
pal-ghk Palmitoyl oligopeptide and pal-gqpr palmitoyl tetrapeptide-7 peptides liposome emulsion.
First we researched for a reliable peptide manufacturer. In the end the choice was surprisingly easy. After contacting numerous local universities we learned that they all use only one manufacturer for the synthesis of peptides used in their research labs.
We ordered our sample peptides, and handed them over to our ODM cosmetic scientist. He then stabilized the peptides by loading them into proteins, and then encapsulated the stabilized peptides into liposomes. The finished product is a stable microemulsion which is ready for formulating.
How many peptides are in the pal-ghk Palmitoyl oligopeptide and pal-gqpr palmitoyl tetrapeptide-7 peptides liposome emulsion?
Peptides are small, really small, and they are counted in ppm (parts per million).
1ppm = 1mg = 0.001g
Matrixyl 3000, which uses the same peptides as our pal-ghk Palmitoyl oligopeptide and pal-gqpr palmitoyl tetrapeptide-7 peptides liposome emulsion
100ppm of Palmitoyl-GHK - Palmitoyl oligopeptide
50 ppm of Palmitoyl GQPR - palmitoyl tetrapeptide-7
The recommended usage for Matrixyl 3000 is 3%
Our pal-ghk Palmitoyl oligopeptide and pal-gqpr palmitoyl tetrapeptide-7 peptides liposome emulsion contains
- Palmitoyl oligopeptide (PAL GHK) 260ppm
- Palmitoyl tetrapeptide-7ppm (PAL GQPR) 140ppm
Why sell a microemulsion instead of the pure powder?
- Peptides are expensive, and sold in grams. A manufacturer will usually take minimum orders of 10 grams, as they are synthesized on demand..
- 2 grams of peptides will make about 4KG of stock solution.
- In the Matrixyl 3000 tests they used 1,3, and 5% of Matrixyl 3000 (Matrixyl 3000 being a stock solution containing 100ppm of Palmitoyl-GHK and 50 ppm of Palmitoyl GQPR )
- Peptides are sold as a freeze dried powder, and must be stored and shipped at a minimum of 4C.
- Dissolving the peptides in their appropriate solvent is relatively easy, loading them into proteins and encapsulating them in liposomes to maintain long term stability at room temperature is not.
- We can most certainly sell our peptides in amounts of 1 gram, contact us if you are interested, but please keep in mind that the costs (including the FedEx temperature-controlled shipping costs) will be high.
About Palmitoyl Oligopeptide
Palmitoyl Oligopeptide is known for considerably stimulating the collagen production in cells that provide structure to connective tissues. These results are seen when this particular peptide is used for a significant amount of time, encouraging firmer skin.
About Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7 boosts reduces the inflammatory response in the skin. Palmitoyl Tetrapeptide-7 also reduces the damage inflicted by exposure to pollution, ultraviolet light and other factors that are known to stress the skin.