Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ?
A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
This ingredient has done more for my skin than anything else I've ever used.
I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic.
I will use this forever, no question... ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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N-acetyl glucosamine is a compound with a wealth of uses for improving skin condition. It is a known precursor to hyaluronic acid, a major component of skin structure. Hyaluronic acid is essential for hydration and n-acetyl glucosamine has been shown to increase moisture. N-acetyl glucosamine helps heal wounds, increase collagen, and reduce acne. It reduces hyperpigmentation, especially when combined with niacinamide, a member of the vitamin B3 family. It has anti-oxidant and anti-inflammatory properties which allow it to help heal and prevent sun damage. Overall, this compound can help prevent premature aging and reduce signs of aging, such as wrinkles, especially when combined with niacinamide.
Key benefits of Glucosamine in skin care:
Stimulate HA production         10]
Moisturizing and hydration    
Treat hyperpigmentation   
Wound healing support  
Stimulate collagen production 
Scar care 
Anti-acne  
Anti-inflammatory  
Anti-oxidant  
Sun damage repair  
Sun damage protection 
Increase skin elasticity  
Reduce fine lines and wrinkles  
Matrix metalloproteinases [MMP] inhibitors 
Product Code: BulkActives Reward Points: 3 Assay:
10036-64-3 Net weight:
30g /1.06oz Availability: In Stock
N-acetyl glucosamine is an amino sugar present in all human tissues . It is a stable form of glucosamine that penetrates skin easily . It is a good cosmetic, as high concentrations of n-acetyl glucosamine do not cause irritation . N-acetyl glucosamine is a precursor to hyaluronic acid, also known as hyaluronan . Hyaluronic acid is a large component of connective tissue and has roles in both skin structure and hydration. The molecule is known to hold water in the skin, increasing moisture . Hyaluronic acid is present in the epidermis and stratum corneum, two different layers of the skin . Cosmetic formulations including n-acetyl glucosamine have many advantages.
Topical n-acetyl glucosamine decreases flakiness, increases skin hydration, and has exfoliating properties . It has been studied as an alternative to alpha hydroxy acids, compounds commonly found in commercial anti-aging treatments that can irritate skin and increase UV damage. An increase in skin elasticity, thickness, and plumping was seen after 8% n-acetyl glucosamine application .
One of n-acetyl glucosamine’s most studied topical uses is for reducing hyperpigmentation . In a clinical study 2% NAG applied topically significantly reduced hyperpigmentation. This is because n-acetyl glucosamine inhibits tyrosinase activation. Tyrosinase is an enzyme involved in melanin synthesis . Hyperpigmentated age spots are localized accumulations of melanin. Thus, by keeping tyrosinase from becoming activated, the amount of melanin produced is less, which decreases the appearance of age spots. When combined with 4% niacinamide, a member of the vitamin B3 family, the pigmentation reducing effect was greater [4, 9]. This shows n-acetyl glucosamine and niacinamide should ideally be used together to produce better results.
An in vitro [outside the body] study shows there is an age-related decrease in glucosamine incorporation into hyaluronic acid. This contributes to wrinkle formation . Studies show that applying n-acetyl glucosamine topically increases hyaluronic acid amounts in the skin . This effect is greater when combined with niacinamide, which is a cofactor in hyaluronic acid synthesis . A clinical study using topical 2% n-acetyl glucosamine showed a reduced appearance of wrinkles . Women using a 2% n-acetyl glucosamine and 4% niacinamide cream showed a larger improvement in fine lines and wrinkles, especially under the eyes . Glucosamine compounds are also known to have anti-inflammatory characteristics . Inflammation can accelerate skin aging, so anti-inflammatory products are useful for preventing this change.
Topical n-acetyl glucosamine also reduces acne [2, 6]. In a clinical study, 8% n-acetyl glucosamine was less drying and irritating than benzoyl peroxide, commonly applied to treat acne . It also helped eliminate acne and was able to reduce acne faster than benzoyl peroxide .
N-acetyl glucosamine increases activity of antioxidant enzymes, thus reducing the amount of harmful free radicals produced after UV exposure. Hyaluronic acid is also known to scavenge free radicals . N-acetyl glucosamine also inhibits matrix metalloproteinases [MMP] that degrade collagen after UV damage . It increases the viability of skin cells exposed to UV radiation. It has also shown to be useful for the prevention of photoaging [premature skin aging due to excessive sun exposure]. Also, hyaluronic acid levels decrease after UV radiation exposure and in sunburned skin . Thus, replenishing hyaluronic acid through application of n-acetyl glucosamine may help heal sun damage.
N-acetyl glucosamine also increases collagen production by fibroblasts [collagen producing cells] . Collagen is important for the structural support of skin. It aids in wound healing and improving elasticity. This study shows the fibroblasts were able to regenerate faster after injury in the presence of n-acetyl glucosamine . Additionally, maintaining an abundance of hyaluronic acid in wounds during the healing process produces better results with less scar formation .
ALL commercially produced Glucosamine, including ours, is manufactured from the shells of crabs and shrimps.
Assay: 99.5% CAS#: 10036-64-3 Chemical Name: N-acetyl-.alpha.-D-glucosamine INCI: acetyl glucosamine Source: ALL commercially produced Glucosamine, including ours, is manufactured from the shells of crabs and shrimps. Appearance: white powder Solubility: water Suggested percentage: 4% Glucosamine with 2% Niacinamide. No other data available - up to customer's discretion. (One DIYer is succesfully using 10% NAG in water with Propylene Glycol.)
Storage: Store in cool and dry place. Keep away from direct strong light and heat. Country of origin: China
 M. Averbeck, C.A. Gebhardt, S. Voigt, S. Beilharz, U. Anderegg, C.C. Termeer, J.P. Sleeman, and J.C. Simon, “Differential Regulation of Hyaluronan Metabolism in the Epidermal and Dermal Compartments of Human Skin by UVB Irradiation,” Journal of Investigative Dermatology, vol. 127, pp. 687–697, 2007.
 D.L. Bissett, “Glucosamine: an ingredient with skin and other benefits,” Journal of Cosmetic Dermatology, vol. 5, pp. 309–315, 2006.
 D.L. Bissett, T. Farmer, S. McPhail, T. Reichling, J.P. Tiesman, K.D. Juhlin, G.J. Hurley, and M.K. Robinson, “Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitro,”
 D.L. Bissett, L.R. Robinson, P.S. Raleigh, K. Miyamoto, T. Hakozaki, J. Li, and G.R. Kelm, “Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine,” Journal of Cosmetic Dermatology, vol. 6, pp. 20–26, 2007.
 B.A. Green, B.L. Edison, R.H. Wildnauer, and R.H. Hwu, “Derivatives of Sugar Compounds Provide Anti-Aging Effects,” Amer Acad of Dermatol Poster Exhibit: Washington, DC, February 2004.
 B.A. Green, R.H. Wildnauer, and B.L. Edison, “Topical N-Acetyl Glucosamine Provides Fast Acne-Reducing Benefits and Mildness Demonstrating Its Potential Utility in Enhancing Conventional Rx or OTC Acne Treatments,” Amer Acad of Dermatol Poster Exhibit, Washington, DC: February 2007.
 Y.P. Hwang, H.G. Kim, E.H. Han, J.H. Choi, B.H. Park, K.H. Jung, Y.C. Shin, and H.G. Jeong, “N- Acetylglucosamine suppress collagenases activation in ultraviolet B-irradiated human dermal fibroblasts: Involvement of calcium ions and mitogen-activated protein kinases,” Journal of Dermatological Science, vol. 63, pp. 93–103, 2011.
 A.B. Kimball, J.R. Kaczvinsky, J. Li, L.R. Robinson, P.J. Matts, C.A. Berge, K. Miyamoto, and D.L. Bissett, “Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial,” British Journal of Dermatology, vol. 162, pp 435–441, 2010.
 T. Mammone, D. Gan, C. Fthenakis, and K. Marenus, “The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin,” J. Cosmet. Sci., vol. 60, pp. 423–428, July 2009.
 R. Osborne, L. A. Mullins, and L. R. Robinson, “Topical N-Acetyl Glucosamine and Niacinamide Increase Hyaluronan,” The Procter & Gamble Company, Cincinnati, Ohio USA.
 A. Połubinska, J. Cwalinski, E. Baum, and A. Brezborowicz, “N-Acetylglucosamine modulates function of the skin fibroblasts,” International Journal of Cosmetic Science, vol. 35, pp. 472– 476, 2013.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.