Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ?
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A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
As all products from bulkactives, this is a really great and high-quality DYI ingredient. Along with John's friendly, reliable and very efficient service, it makes a purchase from bulkactives a very pleasant experience... ...»
I mixed it with some other water actives like Glucosamine, Niacinamide, Glutathione etc into the Pre Liposome Microemulsion and the serum was very smooth and moisturizing. As it claims, it penetrates into the skin very well. I will mix it with oil soluble actives in my next batch. .. ...»
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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BulkActives has been in business since 2005, we might have disappeared from google search results, but we're still hanging on, just, mainly thanks to the support of some loyal customers.
However, like many, COVID hit us hard, and we're having a lot of trouble recovering.
Right now, we have not restocked many powders, however, are looking at continuing with selling only our flagship products:
seakelp and pre-dissolved powders, and some of the essentials.
N-acetyl glucosamine is a compound with a wealth of uses for improving skin condition. It is a known precursor to hyaluronic acid, a major component of skin structure. Hyaluronic acid is essential for hydration and n-acetyl glucosamine has been shown to increase moisture. N-acetyl glucosamine helps heal wounds, increase collagen, and reduce acne. It reduces hyperpigmentation, especially when combined with niacinamide, a member of the vitamin B3 family. It has anti-oxidant and anti-inflammatory properties which allow it to help heal and prevent sun damage. Overall, this compound can help prevent premature aging and reduce signs of aging, such as wrinkles, especially when combined with niacinamide.
Key benefits of Glucosamine in skin care:
Stimulate HA production [2] [3] [4] [5] [6] [7] [8] [9] 10]
Moisturizing and hydration [2] [5] [9] [11]
Treat hyperpigmentation [2] [4] [9]
Wound healing support [2] [11]
Stimulate collagen production [11]
Scar care [2]
Anti-acne [2] [6]
Anti-inflammatory [2] [3]
Anti-oxidant [2] [7]
Sun damage repair [1] [7]
Sun damage protection [7]
Increase skin elasticity [5] [11]
Reduce fine lines and wrinkles [2] [10]
Matrix metalloproteinases [MMP] inhibitors [7]
Product Code: BulkActives Assay:
99.5% CAS#:
10036-64-3 Net weight:
30g /1.06oz Availability: In Stock
N-acetyl glucosamine is an amino sugar present in all human tissues [7]. It is a stable form of glucosamine that penetrates skin easily [4]. It is a good cosmetic, as high concentrations of n-acetyl glucosamine do not cause irritation [9]. N-acetyl glucosamine is a precursor to hyaluronic acid, also known as hyaluronan [2]. Hyaluronic acid is a large component of connective tissue and has roles in both skin structure and hydration. The molecule is known to hold water in the skin, increasing moisture [11]. Hyaluronic acid is present in the epidermis and stratum corneum, two different layers of the skin [9]. Cosmetic formulations including n-acetyl glucosamine have many advantages.
Topical n-acetyl glucosamine decreases flakiness, increases skin hydration, and has exfoliating properties [9]. It has been studied as an alternative to alpha hydroxy acids, compounds commonly found in commercial anti-aging treatments that can irritate skin and increase UV damage. An increase in skin elasticity, thickness, and plumping was seen after 8% n-acetyl glucosamine application [5].
One of n-acetyl glucosamine’s most studied topical uses is for reducing hyperpigmentation [4]. In a clinical study 2% NAG applied topically significantly reduced hyperpigmentation. This is because n-acetyl glucosamine inhibits tyrosinase activation. Tyrosinase is an enzyme involved in melanin synthesis [4]. Hyperpigmentated age spots are localized accumulations of melanin. Thus, by keeping tyrosinase from becoming activated, the amount of melanin produced is less, which decreases the appearance of age spots. When combined with 4% niacinamide, a member of the vitamin B3 family, the pigmentation reducing effect was greater [4, 9]. This shows n-acetyl glucosamine and niacinamide should ideally be used together to produce better results.
An in vitro [outside the body] study shows there is an age-related decrease in glucosamine incorporation into hyaluronic acid. This contributes to wrinkle formation [2]. Studies show that applying n-acetyl glucosamine topically increases hyaluronic acid amounts in the skin [2]. This effect is greater when combined with niacinamide, which is a cofactor in hyaluronic acid synthesis [10]. A clinical study using topical 2% n-acetyl glucosamine showed a reduced appearance of wrinkles [2]. Women using a 2% n-acetyl glucosamine and 4% niacinamide cream showed a larger improvement in fine lines and wrinkles, especially under the eyes [10]. Glucosamine compounds are also known to have anti-inflammatory characteristics [3]. Inflammation can accelerate skin aging, so anti-inflammatory products are useful for preventing this change.
Topical n-acetyl glucosamine also reduces acne [2, 6]. In a clinical study, 8% n-acetyl glucosamine was less drying and irritating than benzoyl peroxide, commonly applied to treat acne [6]. It also helped eliminate acne and was able to reduce acne faster than benzoyl peroxide [6].
N-acetyl glucosamine increases activity of antioxidant enzymes, thus reducing the amount of harmful free radicals produced after UV exposure. Hyaluronic acid is also known to scavenge free radicals [2]. N-acetyl glucosamine also inhibits matrix metalloproteinases [MMP] that degrade collagen after UV damage [7]. It increases the viability of skin cells exposed to UV radiation. It has also shown to be useful for the prevention of photoaging [premature skin aging due to excessive sun exposure]. Also, hyaluronic acid levels decrease after UV radiation exposure and in sunburned skin [1]. Thus, replenishing hyaluronic acid through application of n-acetyl glucosamine may help heal sun damage.
N-acetyl glucosamine also increases collagen production by fibroblasts [collagen producing cells] [11]. Collagen is important for the structural support of skin. It aids in wound healing and improving elasticity. This study shows the fibroblasts were able to regenerate faster after injury in the presence of n-acetyl glucosamine [11]. Additionally, maintaining an abundance of hyaluronic acid in wounds during the healing process produces better results with less scar formation [2].
WARNING
Seafood allergy?
ALL commercially produced Glucosamine, including ours, is manufactured from the shells of crabs and shrimps.
Assay: 99.5% CAS#: 10036-64-3 Chemical Name: N-acetyl-.alpha.-D-glucosamine INCI: acetyl glucosamine Source: ALL commercially produced Glucosamine, including ours, is manufactured from the shells of crabs and shrimps. Appearance: white powder Solubility: water Suggested percentage: 4% Glucosamine with 2% Niacinamide. No other data available - up to customer's discretion. (One DIYer is succesfully using 10% NAG in water with Propylene Glycol.)
Storage: Store in cool and dry place. Keep away from direct strong light and heat. Country of origin: China
[1] M. Averbeck, C.A. Gebhardt, S. Voigt, S. Beilharz, U. Anderegg, C.C. Termeer, J.P. Sleeman, and J.C. Simon, “Differential Regulation of Hyaluronan Metabolism in the Epidermal and Dermal Compartments of Human Skin by UVB Irradiation,” Journal of Investigative Dermatology, vol. 127, pp. 687–697, 2007.
[2] D.L. Bissett, “Glucosamine: an ingredient with skin and other benefits,” Journal of Cosmetic Dermatology, vol. 5, pp. 309–315, 2006.
[3] D.L. Bissett, T. Farmer, S. McPhail, T. Reichling, J.P. Tiesman, K.D. Juhlin, G.J. Hurley, and M.K. Robinson, “Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitro,”
[4] D.L. Bissett, L.R. Robinson, P.S. Raleigh, K. Miyamoto, T. Hakozaki, J. Li, and G.R. Kelm, “Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine,” Journal of Cosmetic Dermatology, vol. 6, pp. 20–26, 2007.
[5] B.A. Green, B.L. Edison, R.H. Wildnauer, and R.H. Hwu, “Derivatives of Sugar Compounds Provide Anti-Aging Effects,” Amer Acad of Dermatol Poster Exhibit: Washington, DC, February 2004.
[6] B.A. Green, R.H. Wildnauer, and B.L. Edison, “Topical N-Acetyl Glucosamine Provides Fast Acne-Reducing Benefits and Mildness Demonstrating Its Potential Utility in Enhancing Conventional Rx or OTC Acne Treatments,” Amer Acad of Dermatol Poster Exhibit, Washington, DC: February 2007.
[7] Y.P. Hwang, H.G. Kim, E.H. Han, J.H. Choi, B.H. Park, K.H. Jung, Y.C. Shin, and H.G. Jeong, “N- Acetylglucosamine suppress collagenases activation in ultraviolet B-irradiated human dermal fibroblasts: Involvement of calcium ions and mitogen-activated protein kinases,” Journal of Dermatological Science, vol. 63, pp. 93–103, 2011.
[8] A.B. Kimball, J.R. Kaczvinsky, J. Li, L.R. Robinson, P.J. Matts, C.A. Berge, K. Miyamoto, and D.L. Bissett, “Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial,” British Journal of Dermatology, vol. 162, pp 435–441, 2010.
[9] T. Mammone, D. Gan, C. Fthenakis, and K. Marenus, “The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin,” J. Cosmet. Sci., vol. 60, pp. 423–428, July 2009.
[10] R. Osborne, L. A. Mullins, and L. R. Robinson, “Topical N-Acetyl Glucosamine and Niacinamide Increase Hyaluronan,” The Procter & Gamble Company, Cincinnati, Ohio USA.
[11] A. Połubinska, J. Cwalinski, E. Baum, and A. Brezborowicz, “N-Acetylglucosamine modulates function of the skin fibroblasts,” International Journal of Cosmetic Science, vol. 35, pp. 472– 476, 2013.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
DISCLAIMER
We do NOT sell ready-made skin care products!
All our products are powders, liquids, flakes or gels, used for making your own skin care products.
All our products are cosmetic / technical grade only.
We do NOT sell pharmaceuticals, prescription drugs or nutritional supplements.
Any statements about our products have not been evaluated by the FDA.
Our active skin care ingredients are not intended to diagnose, treat, cure, or prevent any disease
SHIPPING
Please write your correct address:
We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays.
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.