Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
The Pre-dissolved solution is excellent. Ferulic Acid is an amazing skincare ingredient (potent antioxidant, protects other sensitive antioxidants from light degradation, UV protection) but is absolutely ineffective if it isn't solubilized correctly.
Makes adding to any Serum Base or w/o emulsion easy. Love using it (at 6%; so active 0.5%) with the Resveratrol Fluid (10%; active 1%) and Green Tea Extr for potent nighttime brightening treatment... ...»
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all.
I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making.
At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio !
My thanks again, Helen.. ...»
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Carnitine is a naturally occurring substance, necessary for fat and glucose metabolism in human body cells. Primary function of carnitine in pharmacy is the reduction of advanced glycation end products (AGEs). AGEs are proteins, damaged by reactions with sugars, therefore glycation is most prominent in diabetes patients. It also occurs in many other diseases, as well as natural ageing processes. Dermal carnitine applications reduce the level of glycated collagen and promote synthesis of new protein. Since it is involved in lipid metabolism, carnitine is used for acne treatment. It effectively reduces sebum secretion and skin oiliness. Carnitine preparations also improve other aspects of the skin, such as tonicity, and reduce cellulite. Finally, it aids skin regeneration after damage, such as burns, and promotes blood vessel formation. Regretably, due to Candian law and PayPal regulations, this product may NOT be shipped to Canada.
Key beneftis of Carnitine in skin care:
Oil/sebum control  
Glycation inhibition and repair  
Increase cellular energy production  
Restore barrier function  
Wound-healing support 
Product Code: BulkActives Reward Points: 3 Assay:
3040-38-8 Net weight:
30g /1.06oz Availability: In Stock
Carnitine (also L-carnitine or CA) is a naturally occurring substance, necessary for the cellular metabolism of glucose, fat and related compounds. Since these metabolic processes occur in most cells of the body, carnitine deficiency is associated with a wide range of diseases, such as muscle weakness, cardiac hypertrophy and accelerated atherosclerosis , . Most importantly, carnitine helps to reduce protein glycation levels.
Glycation is a detrimental protein change that occurs in typical ageing processes. It involves a non-specific reaction between various sugars and proteins, especially collagen . The damage brought on by such reactions is irreversible and results in dysfunctional protein aggregates, called advanced glycation end products (AGEs). AGE formation proceeds faster under elevated blood sugar levels, typically caused by diabetes, but they are also involved in the development of other disorders, among them osteoporosis, Alzheimer’s disease and cancer . Carnitine was shown to be successful at inhibiting collagen glycation in rats that were fed on a high-sugar diet .
Furthermore, it reduced the AGE levels even more than commercially used antiglycation agent aminoguanidine, and also enhanced glucose metabolism in the diaphragm. Research on humans also confirms this conclusion, indicating that carnitine successfully reduces AGE levels in skin . It is even suggested for management of adverse chemo- and radiotherapy effects. Recent studies have found that carnitine reduces therapy-caused damage to various organs and possibly even fatigue from chemotherapy .
In skin care, carnitine is a favored ingredient for several purposes.
Due to its role in lipid metabolism, it is known to inhibit sebum secretion and thus reduce skin oiliness. Applying 2 %-carnitine containing cream for 3 weeks was enough to significantly reduce both lipid content and sebum production in human sebaceous glands . The same effect is utilized in anti-acne preparations with carnitine. In a study of mild to moderately severe acne, volunteers used a face cleanser with carnitine for 8 weeks. Total lesion count, sebum production, bacterial colonization, were all reduced; pustule count decreased 5 times, and general life quality of the subjects (measured by a questionnaire test) was improved .
Carnitine can also improve skin appearance in other ways. It is involved in skin cell proliferation, as it was shown to increase epidermal thickness both in healthy skin and during regeneration after wounds , . Using a carnitine-containing preparation for 12 weeks resulted in various esthetic improvements of the skin, such as decreased cellulite and improved tonicity . It is also known to promote wound healing, likely due to increased collagen synthesis, skin cell migration or energy release –. This effect is especially important in patients using steroids, as these medications can reduce the activity of immune processes necessary for wound healing . The healing process can also be disrupted by diabetes, but preparations containing carnitine were effective in such models as well, promoting skin regeneration and faster healing . Benefits of carnitine are not limited to simple wounds – larger burns were also investigated. Carnitine successfully reduced tissue necrosis, promoted cell proliferation, and increased the formation of new blood vessels , . The positive effects on skin cells is enhanced even more when carnitine is combined with retinol (a form of vitamin A) or vitamin C , .
Carnitine exists in two forms: L-Carnitine and D-Carnitine. Only the L-Carnitine form is desirous as the D-Carnitine form is physiologically inactive and can inhibit the uptake and functions of the natural isomer L-Carnitine. BulkActives' Carnitine is L carnitine.
Storage: Keep tightly closed, in cool place. Hygroscopic. Country of origin: China
 K. Fukami, S.-I. Yamagishi, K. Sakai, Y. Kaida, T. Adachi, R. Ando, and S. Okuda, “Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis,” Rejuvenation Res., vol. 16, no. 6, pp. 460–466, Dec. 2013.
 H. A. Khan and A. S. Alhomida, “A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects,” J. Appl. Toxicol. JAT, vol. 31, no. 8, pp. 707–713, Nov. 2011.
 P. Rajasekar and C. V. Anuradha, “L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management,” Acta Diabetol., vol. 44, no. 2, pp. 83–90, Jun. 2007.
 R. I. Peirano, T. Hamann, H.-J. Düsing, M. Akhiani, U. Koop, T. Schmidt-Rose, and H. Wenck, “Topically applied L-carnitine effectively reduces sebum secretion in human skin,” J. Cosmet. Dermatol., vol. 11, no. 1, pp. 30–36, Mar. 2012.
 I. Angelova-Fischer, F. Rippke, T. W. Fischer, G. Neufang, and D. Zillikens, “A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne,” J. Eur. Acad. Dermatol. Venereol. JEADV, vol. 27 Suppl 2, pp. 6–11, Jul. 2013.
 R. Roure, T. Oddos, A. Rossi, F. Vial, and C. Bertin, “Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies,” Int. J. Cosmet. Sci., vol. 33, no. 6, pp. 519–526, Dec. 2011.
 T. Karsidag, J. A. Asensio, F. Kabukcuoglu, and S. Tuzun, “Preliminary study comparing the effects of locally and systemically applied L-carnitine on the healing of full-thickness skin defects,” Scand. J. Surg. SJS Off. Organ Finn. Surg. Soc. Scand. Surg. Soc., vol. 99, no. 3, pp. 147–152, 2010.
 A. Akkus, K. Aydinuraz, C. Daphan, O. Saygun, O. Caglayan, M. Edremitlioglu, and F. Agalar, “Effect of carnitine on cutaneous wound healing in immunosuppressed rats,” J. Surg. Res., vol. 155, no. 2, pp. 301–305, Aug. 2009.
 L. Gennero, R. De Siena, T. Denysenko, M. A. Roos, G. F. Calisti, M. Martano, S. Fiobellot, M. Panzone, S. Reguzzi, L. Gabetti, A. Vercelli, G. Cavallo, E. Ricci, and G. P. Pescarmona, “A novel composition for in vitro and in vivo regeneration of skin and connective tissues,” Cell Biochem. Funct., vol. 29, no. 4, pp. 311–333, Jun. 2011.
 E. Arslan, Y. Basterzi, A. Aksoy, C. Majka, S. Unal, A. Sari, and F. Demirkan, “The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats,” Med. Sci. Monit. Int. Med. J. Exp. Clin. Res., vol. 11, no. 6, pp. BR176–180, Jun. 2005.
 E. Arslan, A. Milcan, S. Unal, F. Demirkan, A. Polat, O. Bagdatoglu, A. Aksoy, and G. Polat, “The effects of carnitine on distally-burned dorsal skin flap: an experimental study in rats,” Burns J. Int. Soc. Burn Inj., vol. 29, no. 3, pp. 221–227, May 2003.
BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.
BulkActives is a part-time business. Orders are processed on Saturdays and mailed on Mondays at the latest.