Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
Many thanks for the Silicone DM. This product is lovely quality; it is light, silky, and leaves no residue at all. I use it in the base recipe for a mouldable polymer that I then use to make a simulated 'Amber' for bead making. At the end of this process I have a silky, translucent polymer plus the most gorgeous hands in the studio ! My thanks again, Helen.. ...»
HELEN pEAKE
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ? -------------------- A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
Diana
I am following the moisturizing cream + Zinc dispersion recipe and I am extremely satisfied. I do allow for a little time for it to absorb in & then I dab off anything that I feel looks a little white - but that's because I initially use a fairly thick coating on myself. I use a bit of foundation at times on top and there are no issues as far as weird colors or texture issues. I am so grateful for this entire website as a one-stop-shop for such effective skin care products, and now we can.. ...»
Peggy
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
The best, most potent and most stable form of Vitamin C. Makes quite a difference to the appearance of mature, photo-damaged skin - don't expect results over night but with consistent use your skin will look more even and radiant!.. ...»
Judy
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Buy Carnosine (L-Carnosine) For Skin Care

Carnosine is a compound from two amino acids, produced naturally in the human brain and muscles. Most likely, it performs a protective function – carnosine neutralizes metal ions and is a powerful antioxidant. It is used in skin care to combat oxidative damage to DNA and proteins, such as that caused by UV exposure. Furthermore, carnosine can protect proteins, primarily collagen, from glycation. These qualities make it a promising molecule in the fight against ageing, as carnosine not only protects cellular components, but can improve the visual appearance, reduce roughness and fine lines. It also maintains the barrier function of the skin, both by simple hydration and complex effects in wound healing. Carnosine applications are of special importance to diabetes patients, as it helps alleviate several complications of this disease, among them xerosis, rapid AGE production, and impaired wound healing.

Key benefits Carnosine in skin care:

  • Glycation inhibitor and repair [1] [9]
  • Sun damage protection [3] [4]
  • Sun damage repair [3] [4]
  • Wound healing support [11] [12]
  • Moisturizing & hydration [13] [14]
  • Antioxidant [4] [5] [6]
  • Restore barrier function [8]
Carnosine (L-Carnosine) skin care active ingredients
Product Code: BulkActives
Reward Points: 7
Assay: 99.8
CAS#: 305-84-0
Net weight: 15g / 0.53oz
Availability: In Stock
Price: $14.50
Reward Points: 725


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Carnosine (L-Carnosine)

About Carnosine in DIY Skin Care

Carnosine is a molecule composed of two amino acids, β-alanine and histidine. It is naturally abundant in brain and muscle tissues, but, although it was discovered in the year 1900, its function in the body is still unclear [1]. It might regulate the pH of muscle cells, neutralize metal ions or act as an antioxidant, and it gained a lot of interest recently as some studies show it might be used in treating cancer, Alzheimer’s disease and even cell ageing [2].

Carnosine has been shown to protect human skin cells against UV radiation. Together with some other forms of radiation, UV causes mutations in DNA and protein damage that often lead to cancer. To combat this, use of DNA-protecting molecules in skin cosmetics was proposed [3]. Carnosine falls among these molecules due to its antioxidant properties. In a study on human skin cells, carnosine was shown to reduce the oxidative damage caused by the UV on both DNA and proteins [4]. It is also able to activate synthesis of other naturally produced antioxidants, such as glutathione peroxidase [5]. Carnosine and related molecules have even stronger antioxidative capability than vitamin E [6]. However, it is advisable to apply these two antioxidants together, not only for synergistic protective effects – vitamin E improves the delivery of carnosine, resulting in higher levels of this molecule in target tissue [7].

In the recent years, commercial sunscreen products started to include carnosine, and the benefits of it have been proven in studies of UV-irradiated skin. Compared to traditional sunscreens, carnosine-containing creams successfully prevented UV damage and resulted in a significantly better state of both DNA and protein (less oxidative damage) after the irradiation [3]. In a trial on volunteers with sensitive skin, carnosine showed a protective effect on skin barrier function (reduced water loss and perceived dryness after 28 days of usage). Biochemical experiments suggest that the cream achieved this by improving the skin and neural cell response to UV radiation [8].

Carnosine is also able to reduce the effects of glycation. This process occurs naturally during ageing and produces damaged forms of proteins, called advanced glycation end products (AGEs). Collagen is among the proteins most affected by this, and its glycation may be responsible for loss of elasticity or other negative consequences of skin ageing. Carnosine is a competitive target for glycation, thus protecting valuable proteins from it [9], [10]. Results from volunteer studies indicate that carnosine improves skin visual parameters, maintains firmness, reduces roughness, fine lines and oily appearance [7].

Another major application of carnosine in skin care is wound healing. A preparation with carnosine was shown to promote collagen synthesis, cell proliferation and migration, which result in faster wound closure [11]. Just like glycation protection, this benefit of carnosine is even more important for diabetes patients, as wound healing is impaired under this disease. Skin applications of carnosine have successfully activated healing in diabetic mice wounds [12]. Xerosis, another skin-affecting complication of diabetes, is also alleviated by applying a cream with carnosine, as this molecule has a hydrating effect [13]. This cream also increases skin thickness, blood circulation and quality of life in xerosis patients [14].
 
Assay: 99.8%
CAS#: 305-84-0
INCI: L Carnosine
Appearance: white powder
Solubility: water
Suggested percentage: 1% to 5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          A. A. Boldyrev, S. C. Gallant, and G. T. Sukhich, “Carnosine, the protective, anti-aging peptide,” Biosci. Rep., vol. 19, no. 6, pp. 581–587, Dec. 1999.
[2]          C. Renner, N. Zemitzsch, B. Fuchs, K. D. Geiger, M. Hermes, J. Hengstler, R. Gebhardt, J. Meixensberger, and F. Gaunitz, “Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model,” Mol. Cancer, vol. 9, p. 2, 2010.
[3]          E. Emanuele, J. M. Spencer, and M. Braun, “An experimental double-blind irradiation study of a novel topical product (TPF 50) compared to other topical products with DNA repair enzymes, antioxidants, and growth factors with sunscreens: implications for preventing skin aging and cancer,” J. Drugs Dermatol. JDD, vol. 13, no. 3, pp. 309–314, Mar. 2014.
[4]          E. Emanuele, M. Bertona, F. Sanchis-Gomar, H. Pareja-Galeano, and A. Lucia, “Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes,” Biomed. Rep., vol. 2, no. 5, pp. 755–759, Sep. 2014.
[5]          M. Y. Kim, E. J. Kim, Y.-N. Kim, C. Choi, and B.-H. Lee, “Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats,” Nutr. Res. Pract., vol. 5, no. 5, pp. 421–428, Oct. 2011.
[6]          M. A. Babizhayev, “Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products,” Life Sci., vol. 78, no. 20, pp. 2343–2357, Apr. 2006.
[7]          M. A. Babizhayev, A. I. Deyev, E. L. Savel’yeva, V. Z. Lankin, and Y. E. Yegorov, “Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging,” J. Dermatol. Treat., vol. 23, no. 5, pp. 345–384, Oct. 2012.
[8]          G. de C. Dieamant, M. D. C. Velazquez Pereda, S. Eberlin, C. Nogueira, R. M. Werka, and M. L. de S. Queiroz, “Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment,” J. Cosmet. Dermatol., vol. 7, no. 2, pp. 112–119, Jun. 2008.
[9]          V. P. Reddy, M. R. Garrett, G. Perry, and M. A. Smith, “Carnosine: a versatile antioxidant and antiglycating agent,” Sci. Aging Knowl. Environ. SAGE KE, vol. 2005, no. 18, p. pe12, May 2005.
[10]        C. Rona, F. Vailati, and E. Berardesca, “The cosmetic treatment of wrinkles,” J. Cosmet. Dermatol., vol. 3, no. 1, pp. 26–34, Jan. 2004.
[11]        Q. Wessels, E. Pretorius, C. M. Smith, and H. Nel, “The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro,” Int. Wound J., vol. 11, no. 2, pp. 152–158, Apr. 2014.
[12]        I. Ansurudeen, V. G. Sunkari, J. Grünler, V. Peters, C. P. Schmitt, S.-B. Catrina, K. Brismar, and E. A. Forsberg, “Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes,” Amino Acids, vol. 43, no. 1, pp. 127–134, Jul. 2012.
[13]        A. Federici, G. Federici, and M. Milani, “An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial,” BMC Dermatol., vol. 12, p. 16, 2012.
[14]        G. Ciammaichella, G. Belcaro, M. Dugall, M. Hosoi, R. Luzzi, E. Ippolito, and M. R. Cesarone, “Product evaluation of Ureadin Rx Db (ISDIN) for prevention and treatment of mild-to-moderate xerosis of the foot in diabetic patients. Prevention of skin lesions due to microangiopathy,” Panminerva Med., vol. 54, no. 1 Suppl 4, pp. 35–42, Dec. 2012.
 
 

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