Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days. Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Eliz
This is great stuff. I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Francisco
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin. *Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Vic
excellence product, very good and made my skin soft and smooth just like baby's skin. Thank you john.. ...»
nky
Im 45 years old; average looking skin for my age. Applied a small pea sized amount of Sea Kelp Bioferment to my face full strength in the am after washing my face of previous night makeup.; let face "dry". Then aplied my foundation as always. Noticed my thick, heavy foundation applied more easily and smooth. Keep in mind this is DAY TWO of me using this. TWO women at work ( separate departments) commented how wonderful my face looked! One specifically came up to me and asked what I was.. ...»
Jessie Sandford
The Pre-dissolved solution is excellent. Ferulic Acid is an amazing skincare ingredient (potent antioxidant, protects other sensitive antioxidants from light degradation, UV protection) but is absolutely ineffective if it isn't solubilized correctly. Makes adding to any Serum Base or w/o emulsion easy. Love using it (at 6%; so active 0.5%) with the Resveratrol Fluid (10%; active 1%) and Green Tea Extr for potent nighttime brightening treatment... ...»
James
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Buy Dipotassium Glycyrrhizinate (White Licorice) For Skin Care

Dipotassium glycyrrhizinate is a salt of glycyrrhizic acid that exhibits several properties that make it useful for cosmetic purposes. Glycyrrhizic acid is also known as glycyrrhizinic acid or glycyrrhizin. It is extracted from licorice (Glycyrrhiza glabra). However, due to glycyrrhizic acid being poorly soluble in water, its potassium salt is frequently utilized instead in skin care products. Dipotassium glycyrrhizinate is a substance well known to the medical community because it has been investigated as potential treatment for several disorders. For example, in Japan it is used as treatment for chronic hepatitis due to its potent antiviral effects. Its beneficial properties can also be transferred to skin care because this licorice constituent displays prominent anti-inflammatory, anti-irritant, anti-aging, anti-psoriatic, anti-allergic and immune modulatory effects..

Key benefits of dipotassium glycyrrhizinate in skin care:

  • anti-inflammatory [3] [4] [6] [8] [9] [10]
  • antioxidant [7] [9]
Dipotassium Glycyrrhizinate (White Licorice) skin care active ingredients
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Product Code: BulkActives
Reward Points: 11
Assay: Dipotassium Glycyrrhizinate 98%
CAS#: 68797-35-3
Net weight: 30g /1.06oz
Availability: Product Out Of Stock
Price: $22.90
Reward Points: 1135


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Dipotassium Glycyrrhizinate (White Licorice)

About Dipotassium Glycyrrhizinate (White Licorice) in DIY Skin Care

Licorice skin careSkin aging can be caused by several factors, including the negative influence of free radicals, trans-epidermal water loss and diminished collagen replacement, among others. Glycyrrhizin exerts anti-aging effects by affecting some of these physiological changes that take place in the human skin, including potent anti-oxidant properties [1],[7],[9]. Dipotassium glycyrrhizinate can be safely incorporated into various cosmetic products because it exhibits no toxicity, as concluded by experts who evaluated various glycyrrhizic acid derivatives [2].

Glycyrrhizin possesses anti-inflammatory properties due to its ability to slow down the metabolism of cortisol, which is a hormone that is implicated in the stress response, but also in the regulation of immune processes [3],[4]. Inflammation is caused by the release of several bioactive molecules, such as prostaglandins and leukotrienes. These pro-inflammatory molecules produce dilation of blood vessels and function as a signal for immune cells to concentrate in the specific area of the body where damage to the tissues, abnormal bacterial proliferation (infection) or irritation have occurred. Signs of skin inflammation (found in dermatitis) may include redness, swelling, itching, “burning” and even pain. Cortisol diminishes the immune response and thus contributes to inflammation resolution.

Dipotassium glycyrrhizinate exerts its anti-inflammatory effects by inhibiting the metabolism of cortisol, which leads to a prolonged half-life and remission of the immune response. Glycyrrhizin also has the ability to decrease the production of prostaglandin E2, which also facilitates the reduction of skin inflammation [6]. This compound (alone or in the form of licorice extract) is widely used in the treatment of atopic dermatitis as a potent anti-inflammatory agent [8], [9], [10].

Glycyrrhizin is currently investigated in clinical studies as a potential treatment for psoriasis [11]. An allergic reaction is accompanied by histamine release from mast cells (also known as degranulation), which causes skin allergy symptoms such as inflammation, itching or skin rash. Glycyrrhizin and its derivatives can ameliorate allergies by inhibiting the degranulation of mast cells, which limits the amount of histamine released into the bloodstream, and by improving the local immune response to an allergen, resulting in a faster resolution of symptoms [5],[7].

Glycyrrhizinic acid is soluble in ethanol only, whereas Dipotassium Glycyrrhizinate is water soluble, thus making it easier and less irritating to use.

Assay: 98%
CAS #: 68797-35-3
INCI: Dipotassium Glycyrrhizinate
Botanical source: glycyrrhiza glabra
Part used: root
Appearance: white powder
Solubility: water
Suggested percentage: No data available - up to customer's discretion.

Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China
[1] Potential Role of Natural Compounds against Skin Aging. Tundis R, Loizzo MR, Bonesi M, Menichini F (2015)
 [2] Cosmetic Ingredient Review Expert Panel (2007).Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate .
 [3] Soma R, Ikeda M, Morise T, Miyamori I, Takeda R (1994) Effect of glycyrrhizin on cortisol metabolism in humans.
[4] Ojima M, Satoh K, Gomibuchi T, Itoh N, Kin S, Fukuchi S, Miyachi Y (1990). The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone
[5] Imanishi N, Kawai H, Hayashi Y, Yatsunami K, Ichikawa A (1989). Effects of glycyrrhizin and glycyrrhetinic acid on dexamethasone-induced changes in histamine synthesis of mouse mastocytoma P-815 cells and in histamine release from rat peritoneal mast cells
[6] Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats
Ohuchi K, Kamada Y, Levine L, Tsurufuji S (1981)
[7] Xiao-Lan Li, Ai-Guo Zhou, Li Zhang, and Wei-Jun Chen (2011). Antioxidant Status and Immune Activity of Glycyrrhizin in Allergic Rhinitis Mice
[8] M Trotta, E Peira, F Debernardi, M Gallarate (2002). Elastic liposomes for skin delivery of dipotassium glycyrrhizinate
[9]  Marjan Nassiri Asl and Hossein Hosseinzadeh (2008). Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds
[10] M Saeedi, K Morteza‐Semnani, and M‐R Ghoreishi (2003). The treatment of atopic dermatitis with licorice gel
[11] Xiong H, Xu Y, Tan G, Han Y, Tang Z, Xu W, Zeng F, Guo Q (2015). Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-α-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells
 

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