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Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Categories
- ALL PRODUCTS
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ACTIVES
- - anti-acne
- - anti-androgenetic alopecia
- - anti-bacterial
- - anti-blackheads
- - anti-inflammatory
- - antioxidant
- - capillary health
- - exfoliating
- - glycation inhibitor and repair
- - increase cellular energy production
- - increase skin elasticity
- - lightening and brightening
- - matrix metalloproteinases (MMP) inhibitors
- - moisturizing and hydration
- - natural phyto estrogens
- - nutrition
- - oil/sebum control
- - pore refinement
- - reduce dark circles under the eyes
- - reduce fine lines and wrinkles
- - reduce rosacea
- - restore barrier function
- - scar care
- - stimulate collagen production
- - stimulate HA production
- - sun damage protection
- - sun damage repair
- - treat hyperpigmentation
- - wound healing support
- - wrinkle relaxers
- - wrinkle tighteners
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- SKIN CARE BASES
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Reviews
This lovely, simple, and affordable product has become something I don't want to be without. I am 47, with very sensitive and reactive dry skin. This cream doesn't feel particularly moisturizing and leaves something of a 'dry' finish on the skin after application, but it's had SUCH a positive impact on my face. The redness and papules from my rosacea and seb derm have reduced by a good 90%. It's been a magical barrier restorer and I panicked when it was temporarily out of stock. I would recomme.. ...»
Candace Carnahan
This is the best product I have ever used on my skin and I tried a LOT of expansive brands. It helps with redness and overall skin tone. Please do not ever stop making this stuff... ...»
Helena
I' m not sure about this: "11% solution gives 1% EGCG content in final product." What is the weight of final product? .. ...»
Vesna Hanich
It is true, this product does leave the skin silky smooth! I can highly recommend using it in your masks... ...»
Mati Fuller
I am 69 and I have used this product for two years almost every day at a high dose, adding it to my antioxidant day cream, with excellent results. For me it has a very high quality and effectiveness: reduction of wrinkles, hydrated skin, unified color without blemishes ... A product of 10, the same score that I give to John for the quality of the products he sells, his excellent description / use and the bibliographic contribution.En .. ...»
María Jesus
Tried this on my week-old rash from flea bites. Got an almost instant relief and rash healed in 2 days.
Tried it on my daughter who has eczema for a very long time. The rashes calmed down after a few days and her skin is now healing well. Really great product. Just put in order for another jar.... ...»
Eliz
This is great stuff.
I add it to my liquid face soap and it does an excellent job in preventing acne and gently exfoliating the skin... ...»
Marie
Really loving this product. I make the best Centella toner and most concentrated ever. 2 g of centella extract dissolved in 10g of alcohol(you have to stir a lot) plus 88 grams of water and you get a very concentrated toner. Creams, toners, ampoules... all have only 0,1% of triterpenes, this toner i make have 1,4%. I am loving it, will see the results. .. ...»
Francisco
Just recently ordered this and LOVE! Green Tea EGCG truly is one of the most fantastic skincare actives out there. Very difficult to find good quality product (90%) and even harder to actually solubilize it! Love that it comes in pre-dissolved solution. I enjoy adding it at 1% (so 11% sol) to my serum formulations containing Niacinamide 5% + NAG 3%. Excellent for oily acne prone skin.
*Only gripe... because the Pre-Dissolved Solution is SO heavy in propanediol (10 parts Propanediol for 1 part E.. ...»
Victor
Wonderful base cream! Only multi-lamellar structured cream I've found on the market. Cream itself is lightweight (no oil) yet very conditioning/hydrating. Easily accepts water-soluble active ingredients as well as oil-soluble ones. I've even pushed the additional ingred % up to 20 (meaning 80% this cream, 20% added) without any separation issues. Ideal base cream for delivering actives. Personal favorite recipe calls for 5% straight Grapeseed Oil with 5% SebumREG oil active + Panthenol 1% + E Ac.. ...»
Vic
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Important Stuff
All customers PLEASE read:
the FAQ and Delivery Info pages!
Canadian Customers:
Any long delivery delays are caused by The Canada Border Services Agency.
I now ONLY offer EMS as a shipping option to Canada.
This appears to have resolved most of the delays caused by The Canada Border Services Agency.
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We take NO responsibility for delivery issues caused by customers entering the wrong address in the checkout page
Delivery
BulkActives is a part-time business. Orders are processed and mailed on Saturdays. (TimeZone Order Deadline Chart)
What we sell
We sell COSMETIC RAW MATERIALS, which are meant to be used at an appropriate percentage in a cosmetic formulation of your devising. Please do not order our products unless you know how to formulate creams and lotions with it!
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Recipe % calculator
Download our SIMPLE RECIPE CALCULATOR (MS Excel)
Sample Recipes
Near The End
BulkActives has been in business since 2005, we might have disappeared from google search results,
but we're still hanging on, just, mainly thanks to the support of some loyal customers.
However, like many, COVID hit us hard, and we're having a lot of trouble recovering.
Right now, we have not restocked many powders, however, are looking at continuing with selling only our flagship products:
seakelp and pre-dissolved powders, and some of the essentials.
Hyaluronic Acid 50 kDa (Low Molecular Weight sodium hyaluronate)
Hyaluronic acid [HA] is an important component of the extracellular matrix. Known to have a role in stimulating dermal fibroblast migration and proliferation as well as for tissue hydration, topical HA has been used in cosmetic applications for decades. Its skin-benefitting properties along with its ability to bind and retain huge amounts of water makes HA ideal for use in anti-wrinkle, anti-aging, and moisturizing creams. HA can exist across a wide range of molecular weights, with the cellular and physiological effects directly depending on the molecular weight of HA present. Therefore, the selection of HA species for use in such creams is of critical importance. High molecular weight HA does not penetrate the epithelium. Very low molecular weight HA, which does penetrate the skin efficiently, can induce a pro-inflammatory response. Recent data indicates that solutions of low molecular weight HA [50 kDa] are best suited for topical use in skin care products as it can penetrate into the skin well but does not cause inflammation. Note: Hyaluronic Acid 50 kDa does not create a thick gel, for this reason we have started selling Sclerotium Gum, the combination of the two ingredients will create an excellent, safe, and efficient product. Warning: Customers in countries with a dry climate may find that hyaluronic acid has a drying effect, instead of moisturizing. It is theorized that this is due to the HA drawing moisturize away from the skin.
Key benefits of Hyaluronic Acid 50 kDa (Low Molecular Weight sodium hyaluronate) in skin care:
- Moisturizing and hydration [2] [3] [4]
- Reduce fine lines and wrinkles [2] [4] [6]
- Increase skin elasticity [2] [4] [6]
- Wound healing support [3] [7]
Product Code: BulkActives
CAS#: 9004-61-9
Net weight: 5g / 0.18oz
Availability: In Stock
CAS#: 9004-61-9
Net weight: 5g / 0.18oz
Availability: In Stock
Price: $13.50
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About Low Molecular Weight Hyaluronic Acid (LMW sodium hyaluronate Powder) in DIY Skin Care
The appearance of the outer layer of the skin, the epidermis, is supported primarily by the dermis and the extracellular matrix it secretes. This matrix, sandwiched between the epidermis and the dermis, is an organized and highly structured environment. While collagen and fibrin primarily make up the support system of this structure, hyaluronic acid [HA] is the filler and cushion which provides the mechanical integrity for that structure. Composed of long chains of non-sulfated glycosaminoglycans, HA contributes to maintenance of the skin through dermal fibroblast cell proliferation and migration [1, 2].Arguably the most important property of HA is its ability to bind water and regulate the hydration of tissues. HA, whose molecular weight can reach into the millions of daltons, can hold hundreds of times its weight of water. Under certain conditions, degradation of HA occurs and results in the appearance of sagging or wrinkled skin. This may happen as a result of infection, wound, or simply the natural aging process [3]. The high water-holding capacity and the contribution to maintenance of the dermal layer of skin makes HA extremely attractive for use in moisturizers and anti-aging creams as well as for wound healing support.
Although commonly used in commercial anti-wrinkle, anti-aging, and moisturizing formulas, high molecular weight HA can actually not efficiently penetrate the barrier of the epidermis [4]. Thus, these creams are not as effective as generally perceived. Further, once in the skin, the physiological effects of HA depend on the molecular size of the HA species present.
Very low molecular weight HA species [approximately 20 kDa or below], actually have pro-inflammatory effects and cause or increase inflammation. These HA species can bind to receptors on macrophages in the dermis, Toll-like receptor 2 and 4, and initiate an immune response [5, 6]. Although potentially useful for wound care, low molecular weight HA confers a negative effect in terms of skin aesthetics. In contrast, high molecular weight HA does not stimulate macrophages to initiate an inflammatory response. This indicates that selection of HA species to be used in cosmetic applications must be done carefully. The HA used must sufficiently penetrate the skin to elicit benefits but must do so without stimulating an immune response.
Recently, studies on HA suggest that formulations containing low molecular weight HA of approximately 50 kDa are ideal. 50 kDa HA efficiently penetrates into the skin as is evidenced by a skin diffusion assay whereas the 300, 800, and 1,500 species penetrated significantly poorer. A trial in which human participants were treated for 8 weeks with a HA topical solution containing 50, 130, or 300 kDa demonstrated that the 50 kDa solution most significantly decreased skin roughness whereas the 300 kDa treatment had no measurable effect. Further, the appearance of wrinkles in the 50 kDa treatment group was significantly decreased [7].
It has been shown that the 800 kDa high molecular weight HA species commonly used in cosmetic formulations can activate approximately 40 genes in keratinocytes which are involved in skin cell regulation and formation of cell-cell tight junctions. In a reconstructed epidermis model in which the skin was treated with high molecular weight HA [800 kDa] or low molecular weight HA [50 kDa], the 50 kDa HA stimulated approximately 120 genes including keratinocyte cell regulation and tight junction proteins. Of note, no pro-inflammatory genes were activated. The additional benefits of the 50 kDa at the molecular level are believed to be directly related to the increased penetration of this species [6, 7].
Note: Hyaluronic Acid 50 kDa does not create a thick gel, for this reason we have started selling Sclerotium Gum, the combination of the two ingredients will create an excellent, safe, and efficient product.
Hyaluronic acid in dry climates
"there is a controversy whether concentrated HA formulas should be used as a moisturizer in dry climate. When air humidity is very low, HA may preferentially pull water from the skin rather than from the air, thus producing the opposite effect." [ Dr. G. Todorov. Hyaluronic acid for skin hydration and possibly a lot more.1999-2015. SmartSkinCare.com]To properly use a hyaluronic acid serum, it needs to be applied onto damp skin and then "sealed" in with a layer of a good moisturizer on top. If applying the hyaluronic acid in this manner still makes your skin feel a bit dry or taut, the hyaluronic acid is probably pulling moisture out of your skin instead of pulling moisture from the air and into your skin.
Note that the combination of Niacinamide and Glucosamine has been proven to actually increase Hyaluronic acid synthesis in the skin, thereby moisturizing from the inside, rather than putting moisture on top of the skin.
Hyaluronic acid in dry climates
"there is a controversy whether concentrated HA formulas should be used as a moisturizer in dry climate. When air humidity is very low, HA may preferentially pull water from the skin rather than from the air, thus producing the opposite effect." [ Dr. G. Todorov. Hyaluronic acid for skin hydration and possibly a lot more.1999-2015. SmartSkinCare.com]To properly use a hyaluronic acid serum, it needs to be applied onto damp skin and then "sealed" in with a layer of a good moisturizer on top. If applying the hyaluronic acid in this manner still makes your skin feel a bit dry or taut, the hyaluronic acid is probably pulling moisture out of your skin instead of pulling moisture from the air and into your skin.
Note that the combination of Niacinamide and Glucosamine has been proven to actually increase Hyaluronic acid synthesis in the skin, thereby moisturizing from the inside, rather than putting moisture on top of the skin.
CAS#: 9067-32-7
INCI: sodium hyaluronate
Source: biotechnology (bacterial fermentation)
Grade: cosmetic grade
Molecular weight: 50 000 Daltons (50 kDa)
Appearance: white powder
Solubility: water (this pure powder dissolves very well in water, some mixing may be required.)
Suggested percentage: 1 to 2%
Unlike regular Hyaluronic Acid, Hyaluronic Acid LMW will not form a viscous gel in water, for this reason we have started selling Sclerotium Gum, the combination of the two ingredients will create an excellent, safe, and efficient product.
Storage: cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
Manufacturing company: Our manufacturer is a UK registered company, with their manufacturing facilities in China. They develop and market innovative ingredients for the Nutritional Market.
Manufacturing low weight NaH: Low molecular weight Hyaluronic acid requires an extra production step compared to normal Hyaluronic acid production. Manufacturers use a chemical method to cut large molecular weight Hyaluronic Acid into low molecular weight. Our normal product is naturally fermented, no animal products are used.
INCI: sodium hyaluronate
Source: biotechnology (bacterial fermentation)
Grade: cosmetic grade
Molecular weight: 50 000 Daltons (50 kDa)
Appearance: white powder
Solubility: water (this pure powder dissolves very well in water, some mixing may be required.)
Suggested percentage: 1 to 2%
Unlike regular Hyaluronic Acid, Hyaluronic Acid LMW will not form a viscous gel in water, for this reason we have started selling Sclerotium Gum, the combination of the two ingredients will create an excellent, safe, and efficient product.
Storage: cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
Manufacturing company: Our manufacturer is a UK registered company, with their manufacturing facilities in China. They develop and market innovative ingredients for the Nutritional Market.
Manufacturing low weight NaH: Low molecular weight Hyaluronic acid requires an extra production step compared to normal Hyaluronic acid production. Manufacturers use a chemical method to cut large molecular weight Hyaluronic Acid into low molecular weight. Our normal product is naturally fermented, no animal products are used.
[1] Brown M, Jones SA. Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of the European Academy of Dermatology and Venereology. 2005;19[3]:308-18.
[2] Price RD, Berry M, Navsaria HA. Hyaluronic acid: the scientific and clinical evidence. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2007;60[10]:1110-9.
[3] Weindl G, Schaller M, Schafer-Korting M, Korting H. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology. 2004;17[5]:207-13.
[4] Brown TJ, Alcorn D, Fraser JRE. Absorption of hyaluronan applied to the surface of intact skin. Journal of investigative dermatology. 1999;113[5]:740-6.
[5] Gariboldi S, Palazzo M, Zanobbio L, Selleri S, Sommariva M, Sfondrini L, et al. Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4. The Journal of Immunology. 2008;181[3]:2103-10.
[6] Farwick M, Gauglitz G, Pavicic T, Köhler T, Wegmann M, Schwach-Abdellaoui K, et al. Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis. Skin pharmacology and physiology. 2011;24[4]:210-7.
[7] Farwick M, Lersch P, Strutz G. Low molecular weight hyaluronic acid: its effects on epidermal gene expression & skin ageing. SÖFW Journal. 2008;134[11]:17.
[2] Price RD, Berry M, Navsaria HA. Hyaluronic acid: the scientific and clinical evidence. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2007;60[10]:1110-9.
[3] Weindl G, Schaller M, Schafer-Korting M, Korting H. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology. 2004;17[5]:207-13.
[4] Brown TJ, Alcorn D, Fraser JRE. Absorption of hyaluronan applied to the surface of intact skin. Journal of investigative dermatology. 1999;113[5]:740-6.
[5] Gariboldi S, Palazzo M, Zanobbio L, Selleri S, Sommariva M, Sfondrini L, et al. Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4. The Journal of Immunology. 2008;181[3]:2103-10.
[6] Farwick M, Gauglitz G, Pavicic T, Köhler T, Wegmann M, Schwach-Abdellaoui K, et al. Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis. Skin pharmacology and physiology. 2011;24[4]:210-7.
[7] Farwick M, Lersch P, Strutz G. Low molecular weight hyaluronic acid: its effects on epidermal gene expression & skin ageing. SÖFW Journal. 2008;134[11]:17.
Click here to download all available sample recipes in a RAR file
Download and unzip using WinZip or 7-Zip (Free)- Unlike regular Hyaluronic Acid, Hyaluronic Acid LMW will not form a viscous gel, for this reason we have started selling Sclerotium Gum, the combination of the two ingredients will create an excellent, safe, and efficient product.
- You can also combine the two Hyaluronic Acids
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