About peptides in DIY Skin Care
Skin is made up mostly of collagen; it is the foundation that gives your skin its support and thickness. Young people have lots of collagen and taut, smooth skin. In contrast, older people have much less collagen and thin, wrinkled skin.
Collagen is protein and is made up long chains of amino acids strung together, like chains of linked building blocks. When it is broken down, short segments of 3-5 amino acids form, called peptides.
When we age collagen is destroyed but not replaced. As a result young, smooth becomes thin and wrinkled over time.One strategy to improve winkles and to make you look younger is to replace lost collagen. When collagen breaks down, it forms specific peptides. These peptides act as a signal to tell your skin it was damaged and to make new collagen.
Peptides are proteins composed of long or short chains of amino acids, which are the building blocks of protein. Peptides may be natural or synthetic. Most peptides used in cosmetics are synthetic because labs engineering these ingredients gives chemists greater control on their stability and effectiveness in skin-care products.
Applying peptides directly to your skin is a way to trick your skin into thinking that it has lost collagen recently and needs to make more.
About Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 peptides liposome emulsion in DIY Skin Care
The combination of the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 has been shown to help repair UV induced skin damage (sun damage) and reverse signs of chronological ageing.
A 2011 (company sponsored) In vivo study demonstrated the positive matrix reinforcing effect the combination of the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7. A significant improvement corresponding to a gain in age of 1.8 years was visible in just one month, and confirmed after 2 months: the photo-induced ageing was then delayed by 5.5 years.
Another analysis of the papillary dermis showed that the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 helped reduce the fiber fragmentation and supported the reconstruction of the papillary dermal fibre network.
This test confirmed the repairing effects of the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7: promotion of wrinkle smoothing and improvement of skin tone and elasticity.
A 2013 (company sponsored) proved that the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 significantly stimulated synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins.
While these proteins usually decrease with age, the two peptides Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 rejuvenated the dermal structure and tended to make ageing skin behave like young skin.
Read more here: 2011 and 2013 Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 tests
and palmitoyl oligopeptide & palmitoyl-tetrapeptide-7 : Back to the future of anti-aging skin care
About Palmitoyl Oligopeptide in Skin Care
Palmitoyl Oligopeptide is an amino-peptide that when added to a culture of fibroblasts (key skin cells), stimulates collagen, elastin and glucosaminoglycans production. These are the key components of healthy-looking skin.
Clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production, Palmitoyl Oligopeptide is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin.
As with Palmitoyl Pentapeptide-3, one could look at Palmitoyl Oligopeptide as a man-made precursor to collagen. Palmitoyl Oligopeptide was developed through research to identify a substance that would behave similarly to retinoic acid but without its drawbacks, especially in regards to synthesizing collagen.
The reported results of topical application of Palmitoyl Oligopeptide are as follows:
- Increases collagen production by the fibroblasts by as much as 350%.
- Increases hyaluronic acid production by the fibroblasts by as much as 146%.
In vivo: The following statistics were gathered using image analysis of volunteers who used crèmes containing a 3% concentration of Palmitoyl Oligopeptide for 28 days.
- Surface roughness -- Reduced 17%
- Mean depth of wrinkles -- Reduced 23%
- Depth of main wrinkle -- Reduced 39%
- Skin thickness -- Increased 4%. The increase in skin thickness was considered especially notable and contrasts with the 6% reduction of the skin thickness that occurs after 10 years of aging.
Palmitoyl Oligopeptide is a potent active cosmetic ingredient without the adverse effects (including irritation, dehydration or long-term toxicity and instability) characteristic of retinoids.
About Palmitoyl Tetrapeptide 7 in Skin Care
Palmitoyl Tetrapeptide-7 has been clinically proven to suppress the body's production of interleukins (IL6), the chemical messengers that trigger inflammation, the first step in the aging cascade.
Inflammation is a function of immunity and is a protective response to injury or destruction of tissue. This is the body's way of walling off the injurious agent and the injured tissue. Under normal circumstances, very little IL6 is secreted and its secretion is strictly controlled. However, as we age this regulation system develops defects, and significant levels of IL6 appear in the plasma even when there is no inflammatory stimulus. This results in high levels of inflammatory proteins in the tissues and a loss of healing potential.
At concentrations from 10 ppm, Palmitoyl Tetrapeptide-7 induces a marked reduction in the secretion of the cytokine IL6. This reduction is progressive and depends on the concentration of the peptide: baseline secretion may be inhibited by up to 40%.
Palmitoyl Tetrapeptide-7 reduced levels of IL6 after cells were exposed to UV radiation by up to 86% even though IL6 had been increased by about 20 fold by the UV. These results show that Palmitoyl Tetrapeptide-7 is able to affect baseline levels of IL6 as well as modulate the effects of UV-stimulated over-production of IL6.
Palmitoyl Tetrapeptide-7 is a molecule that can restore cytokine equilibrium, which characterizes youthful skin.
BulkActives Peptide Liposome Emulsion
Palmitoyl oligopeptide (PAL GHK) 260ppm
Palmitoyl tetrapeptide-7 ppm (PAL GQPR) 140ppm
Twice the strength of Matrixyl 3000
Download and unzip using WinZip
: water, peptides are pre dissolved and stabilized
add at the end of the emulsion, at cool down, below 40C (104F), OR simply add water and mix well to create an thin elegant serum.
: 1.5% to 4%