Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
Carla, Many medications can be and are applied topically by prescription. With that in mind, realize that this particular ingredient is wonderful but understand that this is indeed one of those that may create sensitivity with those already using topical hormones or just use sparingly and see how you respond. Sorry for the very late response..... ...»
Angela
Very good product! Only been using it for a short time, its already made a difference. .. ...»
Bronwynne
muy satisfecho profesionales, y envio sin problemas ,ya que soy de españa producto bien envasado , un placer ser cliente porque dan comnfianza y calidad.gracias un saludo.. ...»
daniel
Wanting to try this, but.... Angela, what was that about effecting hormones? Could someone explain please..... ...»
Carla
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ? -------------------- A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
Diana
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
The best, most potent and most stable form of Vitamin C. Makes quite a difference to the appearance of mature, photo-damaged skin - don't expect results over night but with consistent use your skin will look more even and radiant!.. ...»
Judy
I purposely waited a few months before writing my review. I am happy to report this product is great! I combined the DMAE product with the base creams resulting in tighter skin and lessened wrinkles, including areas around underarms... ...»
cjmluv
Very good product. It performed exactly how I expected. .. ...»
Ryan
This ingredient has done more for my skin than anything else I've ever used. I put it into a spray facial toner and use it morning and night. I noticed the effects immediately, they were that dramatic. I will use this forever, no question... ...»
Marie
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Buy Creatine Pyruvate For Skin Care

Creatine is a molecule synthesized naturally in the human body. It is most important in tissues where energy-requiring activities occur, as it is involved in maintaining constant energy flow inside the cell.  It was show to protect skin from degeneration during ageing: creatine activates collagen synthesis, in this way decreasing the amount of wrinkles, and restoring skin firmness, smoothness and elasticity. Cheek sagging can also be reduced by applying creatine-containing cream. Another important benefit of creatine is UV damage protection, as it helps to protect cellular structures (especially mitochondria) from oxidative stress and mutations. Furthermore, creatine-treated skin was shown to regenerate faster. However, to protect creatine itself, pairing with coenzyme Q10 or other antioxidants is advised.

Key benefits of Creatine in skin care:

  • Sun damage protection [6] [7] [8] [9]
  • Sun damage repair [6] [7]
  • Increase cellular energy production [1] [3] [7]
  • Increase skin elasticity  [6]
  • Reduce fine lines and wrinkles [2] [6]
  • Stimulate collagen production [2] [4]
Creatine Pyruvate skin care active ingredients
Product Code: BulkActives
Reward Points: 5
Assay: 99.8
CAS#: 55965-97-4
Net weight: 30g /1.06oz
Availability: In Stock
Price: $5.30
Reward Points: 535


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Creatine Pyruvate

About Creatine Pyruvate in DIY Skin Care

Creatine is a molecule synthesized from amino acids in human liver, kidneys and pancreas. It is well-known for its function in metabolism – it helps to maintain constant energy flow for intense energy-requiring activities, such as muscle contractions during exercise [1]. Therefore, creatine supplements for athletes have been researched in great detail. Recently, however, it has attracted attention as a promising ingredient in cosmetics, since it can be rapidly absorbed through skin [2]. As energy flow occurs in every cell, the benefits of creatine are very diverse. In epithelial skin cells, the functions of this molecule are associated with cell proliferation, hair growth, sebum secretion and even wound healing [3].

It has been suggested that cellular energy metabolism is related to collagen degeneration during ageing. In fact, dermal application of creatine and guarana extract was shown to overcome this problem by activating collagen synthesis [2]. The same effect was found using a mixture of creatine and folic acid, indicating that creatine indeed is the ingredient responsible for these benefits. In this case, increased firmness of the skin was also observed [4].  To investigate the effects on visual skin appearance, volunteers applied a creatine-containing cream for 6 weeks and were evaluated by experts. It was found that the cream significantly reduced cheek sagging, crow’s feet wrinkles and wrinkles under the eyes [2]. Among other ingredients, creatine was used in a complex anti-ageing gel which noteably reduced cellulite symptoms in 81 % of volunteers treated [5].

Creatine is also involved in repairing skin damage after UV exposure or photoageing. Again, applied together with folic acid, creatine caused faster cell proliferation, thus stimulating renewal of the damaged skin tissue. This resulted in increased skin firmness, reduced number of both fine and coarse wrinkles, as well as increased smoothness and elasticity [6]. Additionally, a protective effect of creatine has been documented, for example, it decreases the DNA damage caused by UV radiation [6]. Other research also indicate that creatine is able to both protect the cells from UV and repair the damage caused by it, possibly by providing the energy necessary for these activities [7].

Mitochondria – the cell structures where respiration and energy generation occur – constantly generate oxidants as by-products, and thus are sensitive to irradiation or other oxidizing stresses. Creatine can also be transported to this structure, where it helps to reduce ageing-associated mutations and in this way also functions in tumor prevention [8]. In another study, application of 1 % cream was sufficient to completely negate the damage done to mitochondria by irradiation. This experiment was performed with elderly volunteers (average of 65 years), as additional supplements of creatine were shown to be more important at this age [9].

While creatine is not a known antioxidant, it can help protect certain enzymes and other proteins from oxidative damage [9]. However, this makes creatine itself susceptible to oxidation. Therefore, it is advised to pair it with a strong antioxidant – for example, including coenzyme Q10 in the formulation was shown to protect creatine and such combination results in even higher effectiveness against skin ageing symptoms [10].
 

About Creatine and Carnitine in DIY Skin Care

A newly issued patent, entitled, “Use of Creatine or Creatine Compounds for Skin Preservation,” claims that topical application of a combination of Creatine and Carnitine treats uneven skin pigmentation.
Assay: 99.8%
CAS No.:  55965-97-4
INCI: Creatine Pyruvate
Appearance: white powder
Odor: Strong, unpleasant sour smell.
Solubility: water, heated to 43C (110F), to ensure that crystals dissolve
Suggested percentage:0.5% to 1.5%

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          B. Gualano, H. Roschel, A. H. Lancha-Jr, C. E. Brightbill, and E. S. Rawson, “In sickness and in health: the widespread application of creatine supplementation,” Amino Acids, vol. 43, no. 2, pp. 519–529, Aug. 2012.
[2]          R. I. Peirano, V. Achterberg, H.-J. Düsing, M. Akhiani, U. Koop, S. Jaspers, A. Krüger, H. Schwengler, T. Hamann, H. Wenck, F. Stäb, S. Gallinat, and T. Blatt, “Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects,” J. Cosmet. Dermatol., vol. 10, no. 4, pp. 273–281, Dec. 2011.
[3]          T. Wallimann, M. Tokarska-Schlattner, and U. Schlattner, “The creatine kinase system and pleiotropic effects of creatine,” Amino Acids, vol. 40, no. 5, pp. 1271–1296, May 2011.
[4]          F. Fischer, V. Achterberg, A. März, S. Puschmann, C.-D. Rahn, V. Lutz, A. Krüger, H. Schwengler, S. Jaspers, U. Koop, T. Blatt, H. Wenck, and S. Gallinat, “Folic acid and creatine improve the firmness of human skin in vivo,” J. Cosmet. Dermatol., vol. 10, no. 1, pp. 15–23, Mar. 2011.
[5]          E. Dupont, M. Journet, M.-L. Oula, J. Gomez, C. Léveillé, E. Loing, and D. Bilodeau, “An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy,” Clin. Cosmet. Investig. Dermatol., vol. 7, pp. 73–88, 2014.
[6]          A. Knott, U. Koop, H. Mielke, K. Reuschlein, N. Peters, G.-M. Muhr, H. Lenz, U. Wensorra, S. Jaspers, L. Kolbe, T. Raschke, F. Stäb, H. Wenck, and S. Gallinat, “A novel treatment option for photoaged skin,” J. Cosmet. Dermatol., vol. 7, no. 1, pp. 15–22, Mar. 2008.
[7]          D. Maes, D. Collins, L. Declercq, R. Foyouzi-Yousseffi, D. Gan, T. Mammone, E. Pelle, K. Marenus, and H. Gedeon, “Improving cellular function through modulation of energy metabolism,” Int. J. Cosmet. Sci., vol. 26, no. 5, pp. 268–269, Oct. 2004.
[8]          M. Berneburg, T. Gremmel, V. Kürten, P. Schroeder, I. Hertel, A. von Mikecz, S. Wild, M. Chen, L. Declercq, M. Matsui, T. Ruzicka, and J. Krutmann, “Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences,” J. Invest. Dermatol., vol. 125, no. 2, pp. 213–220, Aug. 2005.
[9]          H. Lenz, M. Schmidt, V. Welge, U. Schlattner, T. Wallimann, H.-P. Elsässer, K.-P. Wittern, H. Wenck, F. Stäb, and T. Blatt, “The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo,” J. Invest. Dermatol., vol. 124, no. 2, pp. 443–452, Feb. 2005.
[10]        T. Blatt, H. Lenz, U. Koop, S. Jaspers, T. Weber, C. Mummert, K.-P. Wittern, F. Stäb, and H. Wenck, “Stimulation of skin’s energy metabolism provides multiple benefits for mature human skin,” BioFactors Oxf. Engl., vol. 25, no. 1–4, pp. 179–185, 2005.
 
0.5 to 1.5% added to water phase, then heated to 43C (110F), ensuring that crystals dissolve

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