Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients, for DIY skin care and cosmetics, and homemade skin care products.
Reviews
I wished i could order this in a smaller amount of 50 gr. Can i get informed when it is available ? -------------------- A. It will not be sold in smaller amounts. The review rating is meant to be for the product, not the size in which it is sold :-(.. ...»
Diana
Excellent quality, very fine texture and disperses easily when used correctly. Arrived in just seven days to London, England and with a reasonable postage fee. Very pleased... ...»
D N Bay
I bought this product before and I am here to buy it again! A high quality product for really good price... .. Thanks!.. ...»
Raisa
As all products from bulkactives, this is a really great and high-quality DYI ingredient. Along with John's friendly, reliable and very efficient service, it makes a purchase from bulkactives a very pleasant experience... ...»
Sandra
I mixed it with some other water actives like Glucosamine, Niacinamide, Glutathione etc into the Pre Liposome Microemulsion and the serum was very smooth and moisturizing. As it claims, it penetrates into the skin very well. I will mix it with oil soluble actives in my next batch. .. ...»
RRR
Awesome Product and thanks for such a nice Product description .. ...»
Stephen
Excellent product! Easy to use. Add to your cream or oil, mix, and that's it! After applying cream with peptides, my skin was really smooth and nourishing. Very happy that BulkActives offers such high quality product for really good price... ...»
Nativa
Great product! I've added this emulsion to different DYI combinations to include serums and creams with wonderful results. It's a light, smooth product that mixes easily into my formulations. As earlier reviewer mentioned, I especially like the emulsion when mixed with the incredible multi-lamellar IV cream. Also, can't beat the price for such a quality product... ...»
Annabelle
Hi, Ordered this about 5 weeks ago, so I been waiting to DIY and try the product before I left a review. I mixed Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 Liposome Emulsion, 3/4 tsp, with 3tsps distilled water and 3/4 tsp of rose hip oil. It makes a beautiful light weight serum that I apply at night. You can feel tightening within a few minutes. The tightening subsides in half hour or so and then I apply a moisturiser. Another excellent buy from Bulk Actives. .. ...»
Jan Greenwood
I've been using glucosamine in combination with niacinamide as an addition to my moisturizer to combat dark spots on face and hands. Used twice daily, it does seem to keep them from darkening. Of course, you still need to be religious about using a sunscreen every time you are in the sun. .. ...»
Lorraine
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Buy GABA (Gamma-aminobutyric acid) For Skin Care

GABA (gamma-aminobutyric acid) is a neurotransmitter with purported dermatological benefits. Several patents indicated that GABA can be used as a wrinkle relaxer based on its inhibitory effect on muscles. Some patents also claim that GABA can dilate skin peripheral blood vessels, moisturize and prevent aging, suppress parakeratosis and shrink pores, as well as whitening the skin. However there is no scientific data to support these claims. On the other hand, a preliminary research study has shown that GABA can stimulate hyaluronic acid synthesis and protect the fibroblasts from oxidative stress. Another study showed that GABA was able to upregulate beta-defensin-2, which is an anti-microbial peptide, and filaggrin, which plays a role in normal barrier function of the skin. Lastly, GABA might be useful in combating inflammation associated with psoriasis based on preliminary findings that GABA receptors are expressed in white blood cells in psoriatic skin. Overall, the evidence of GABA in supporting skin health is very weak, and consumers are warned for its application.

Unsubstantiated benefits of GABA (Gamma-aminobutyric acid) in skin care:

  • Anti-bacterial [11]
  • Anti-inflammatory [12]
  • Anti-oxidant [10]
  • Capillary health [4][5][6]
  • Lightening and brightening [8][9]
  • Moisturizing and hydration [4][5][6][11]
  • Pore refinement [7]
  • Reduce fine lines and wrinkles [2][3][4][5]
  • Restore barrier function [11]
  • Stimulate HA production [10]
  • Wrinkle relaxers [2][3][4][5]
GABA (Gamma-aminobutyric acid) skin care active ingredients
Product Code: BulkActives
Reward Points: 3
CAS#: 56-12-2
Net weight: 30g /1.06oz
Availability: In Stock
Price: $5.10
Reward Points: 255


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GABA (Gamma-aminobutyric acid)

About GABA (Gamma-aminobutyric acid) in DIY Skin Care

Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter. In the mature brain of humans, it exerts inhibitory function on neurons when bind to GABA receptors, through regulating the chloride gradient across the cell membrane. GABA is synthesized by enzymes called glutamate decarboxylase, using glutamate as the substrate. Once synthesized, it is transported in little vesicles to the synapses of the neurons, and its action depends on its metabolism, expression, and activity level. GABA is important for brain development, and its dysfunction has been linked to a myriad of neurological disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.[1]

GABA has been marketed as a wrinkle relaxer based on the claim that it can inhibit neuronal activity and hence relax muscles, limiting the “expression lines” resulted from muscle hyper-contraction such as in the peri-oral regions. There are several patents that indicate such function when used topically.[2][3][4][5] Other patents that mentioned GABA’s benefits include dilation of skin peripheral blood vessels,[4][5][6] moisturizing and age-preventing,[4][5][6] suppressing parakeratosis and pore shrinking,[7] and whitening effects.[8][9] However, there have been no peer-reviewed study published to date (May, 2015) on these effects.

Research on dermatological use of GABA has been sporadic. It has been shown that glutamate decarboxylase exists in human dermal fibroblasts, and GABA can stimulate the synthesis of hyaluronic acid and enhances the survival rate of the fibroblasts when exposed to oxidative stress in vitro.[10] GABA synthesized from fermentation of grape must using bacteria (Lactobacillus plantarum) has been shown to increase the level of beta-defensin-2, hyaluronan synthase, and filaggrin in reconstituted human skin tissue,[11] suggesting that GABA might play a role in anti-microbial function, hydration, and proper barrier function of the skin. GABA receptors are expressed in a number of white blood cell types in psoriatic skin, and GABA has been implicated to be important in relieving inflammation associated with psoriasis.[12] These studies provide new possibilities for the application of GABA, however consumers are encouraged to exercise precautions due to the fact that none of these studies has been replicated and substantiated.
Assay: 99.6%
CAS No.: 56-12-2
INCI: Gamma-AminoButyric Acid
Appearance: white powder
Solubility: water
Suggested percentage: No data available, up to customer's discretion

Storage: Cool, dry place. Do not freeze. Keep away from light and moisture!
Country of origin: China
[1]          G. Deidda, I. F. Bozarth, and L. Cancedda, “Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives,” Front. Cell. Neurosci., vol. 8, May 2014.
[2]          O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5976559 A, 02-Nov-1999.
[3]          O. D. Lacharriere and L. Breton, “Compositions and methods for treating wrinkles and/or fine lines of the skin,” US5869068 A, 09-Feb-1999.
[4]          H. Kyotaro and H. Minoru, “Cosmetic for preventing skin from aging,” 05-043448, 23-Feb-1993.
[5]          T. Hiroshi, “Cosmetic for preventing aging of skin,” 05-117137, 14-May-1993.
[6]          O. Tadatake, A. Takashi, and H. Kyotaro, “Cosmetic for preventing aging of skin,” 60-184005, 19-Sep-1985.
[7]          M. Kaminuma, M. Suetsugu, T. Iida, and S. Inomata, “Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin,” US20120232111 A1, 13-Sep-2012.
[8]          S. Tatsuro and T. Hiroshi, “Skin-whitening cosmetic,” 05-229929, 09-Jul-1993.
[9]          T. Hiroshi and S. Tatsuro, “Skin-beautifying cosmetic,” 05-194178, 08-Mar-1993.
[10]        K. Ito, K. Tanaka, Y. Nishibe, J. Hasegawa, and H. Ueno, “GABA-synthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function,” Biochim. Biophys. Acta, vol. 1770, no. 2, pp. 291–296, Feb. 2007.
[11]        R. Di Cagno, F. Mazzacane, C. G. Rizzello, M. De Angelis, G. Giuliani, M. Meloni, B. De Servi, and M. Gobbetti, “Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications,” Appl. Microbiol. Biotechnol., vol. 86, no. 2, pp. 731–741, Mar. 2010.
[12]        R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role,” Arch. Dermatol. Res., vol. 302, no. 7, pp. 507–515, Sep. 2010.

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